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VANGUARD WORKSHOPS

Ethics of early clinical trials in regenerative medicine in transplantation | Online, Thursday 3 February 2022

Bio-artificial organs and bio-engineered or bio-printed tissues for transplantation in humans are rapidly being developed. It is anticipated that some applications will be ready for clinical testing in the near future. How can first-in-human clinical trials be conducted in a safe and responsible manner? What are ethical points to consider for early clinical trials of regenerative medicine in transplantation? This workshop brings together experts in the fields of regenerative medicine and ethics to discuss these ethical challenges.

This video shows the full recording of the VANGUARD Ethics workshop held online, Thursday 3 February 2022 from 16:0018:00.

SCIENTIFIC PUBLICATIONS

Below is a list of all accepted VANGUARD scientific publications available to date. Further publications as well as conference posters, proceedings and presentations will be added when available.

  1. TRANSPLANT INTERNATIONAL, 2022
    Bio-Engineering of Pre-Vascularized Islet Organoids for the Treatment of Type 1 Diabetes
    Wassmer CH, Lebreton F, Bellofatto K, Perez Lisa, Cottet-Dumoulin D, Andres A, Bosco D, Berney T, Othenin-Girard V, Martinez de Tejada B, Cohen M, Olgasi C, Follenzi A, Berishvili E.
  2. STEM CELL REVIEW AND REPORTS, 2021
    Mechanisms of Immunomodulation and Cytoprotection Conferred to Pancreatic Islet by Human Amniotic Epithelial Cells
    Lebreton F, Hanna R, Wassmer CH, Bellofatto K, Perez L, Othenin-Girard V, Martinez de Tejada B, Cohen M, Berishvili E.
  3. NATURE METABOLISM, 2020
    I’ve got you under my skin
    Berney T, Berishvili E.
  4. TRANSPLANT INTERNATIONAL, 2020
    Generation of insulin-secreting organoids: a step toward engineering and transplanting the bioartificial pancreas
    Wassmer CH, Lebreton F, Bellofatto K, Bosco D, Berney T, Berishvili E.
  5. CURRENT DIABETES REPORTS, 2020
    Immunomodulatory Properties of Amniotic Membrane Derivatives and Their Potential in Regenerative Medicine

    Wassmer CH, Berishvili E.
  6. STEM CELL REVIEWS AND REPORTS, 2020
    Treatment of COVID-19 Pneumonia: the Case for Placenta-derived Cell Therapy

    Berishvili E, Kaiser L, Cohen M, Berney T, Scholz H, Floisand Y, Mattsson J.
  7. MEDICAL SCIENCES, 2020
    Organoïdes sécréteurs d’insuline : des «super-îlots» comme premier pas vers le pancréas bioartificiel
    Lebreton F, Wassmer CH, Bellofatto K, Berney T, and Berishvili E.
  8. CELL TRANSPLANTATION. 2020
    Engineering of Primary Pancreatic Islet Cell Spheroids for Three-dimensional Culture or Transplantation: A Methodological Comparative Study

    Wassmer CH, Bellofatto K, Perez L, Lavallard V, Cottet-Dumoulin D, Ljubicic S, Parnaud G, Bosco D, Berishvili E, Lebreton F.

PUBLIC REPORTS

VANGUARD continuously reports its results and progress to the European Commission. Some of these reports (called “Deliverables”) are public and once submitted are made available for download here.

  • D9.1 Project website, due 29/02/2020, download available
  • D9.4 VANGUARD Communication Portfolio, due 30/06/2022
  • D2.1 ELSA Training Manual, due 31/12/2022
  • D2.2 Guidelines on ethical, social, legal and psychological aspects of VANGUARD, due 31/12/2022
  • D9.3 VANGUARD Stakeholder Engagement and Dissemination Assessment Reports, due 31/12/2023
  • D9.7 Policy brief, due 31/12/2024
  • D9.8 Final project event and EU Parliament workshop, due 31/12/2024

* Please note that these deliverables are undergoing review and acceptance processes. At this stage this deliverable reflects only the author’s view and the European Commission is not responsible for any use that may be made of the information it contains.