The Relevance of Advanced Therapy Medicinal Products in the Field of Transplantation and the Need for Academic Research Access: Overcoming Bottlenecks and Claiming a New Time
VANGUARD partners have published a publication titled The Relevance of Advanced Therapy Medicinal Products in the Field of Transplantation and the Need for Academic Research Access: Overcoming Bottlenecks and Claiming a New Time as part of the Transplant International special issue on The Future of Beta Cells Replacement in the Era of Regenerative Medicine and […]
Open access publication published in haematologica
A new VANGUARD article on Therapeutic potential of fetal liver cell transplantation in hemophilia A mice has recently been published in haematologica. The publication is available open access online: https://haematologica.org/article/view/haematol.2022.282001 Abstract Hemophilia A (HA) cell therapy approaches in pediatric individuals require suitable factor (F)VIII-producing cells for stable engraftment. Liver sinusoidal endothelial cells (LSEC) and hematopoietic […]
Watch the VANGUARD project video online
During the annual VANGUARD project meeting 2022 held in Geneva, Switzerland we spoke to all project partners involved about the objectives of VANGUARD, their role within the project and the possible impact generating a vascularized and immune-protected bioartificial pancreas that can be transplanted into non-immuno-suppressed patients can have. The interview is now available online and […]
VANGUARD publication is Transplant International special issue
VANGUARD project partners have published a open access research article titled Formation of Re-Aggregated Neonatal Porcine Islet Clusters Improves In Vitro Function and Transplantation Outcome as part of a special issue in Transplant International on The Future of Beta Cells Replacement in the Era of Regenerative Medicine and Organ Bioengineering. Abstract Neonatal porcine islet-like cell clusters (NPICCs) […]
New publication: Early-Phase Clinical Trials of Bio-Artificial Organ Technology: A Systematic Review of Ethical Issues
A new VANGAURD publication titled Early-Phase Clinical Trials of Bio-Artificial Organ Technology: A Systematic Review of Ethical Issues has been published in Transplant International as part of a special issue on Ethical issues in organ donation and transplantation. The full article is available open access, read it online here: https://www.frontierspartnerships.org/articles/10.3389/ti.2022.10751/full Abstract Regenerative medicine has emerged […]
Presentation at 29th International Congress of The Transplantation Society
VANGUARD was presented at the 29th International Congress of The Transplantation Society (TTS 2022) which was held in Buenos Aires from 10-14 September 2022. The abstract for the VANGUARD presentation titled Generation of Prevascularized Endocrine Constructs to Treat Type 1 Diabetes is available online and was published in Transplantation as part of the conference proceedings.
VANGUARD publication on Ethics of Early Clinical Trials of Bio-Artificial Organs available online
A new VANGUARD publication has recently been made available in Transplant International. Its name is “Ethics of Early Clinical Trials of Bio-Artificial Organs” and the publication outlines the ethical challenges addressed by Erasmus University Medical Center Rotterdam team. Although the social value of bio-artificial organs can be undoubtedly enormous, the VANGUARD project is also evaluating […]
New publication on the generation of pre-vascularised organoids
The VANGUARD consortium recently published collaborative work in the journal Transplant International on the generation of pre-vascularised organoids. The authors from the University of Geneva and the University of Eastern Piedmont show that pre-vascularized islet organoids exhibit enhanced in vitro function compared to native islets, improved engraftment and accelerated vascularization in vivo in a murine […]
VANGUARD presented at the SFT Congress
Our coordinator Dr Ekaterine Berishvili took a part in the 2021 Société Francophone de Transplantation to share the progress of the VANGUARD project.
New Publication: Mechanisms of Immunomodulation and Cytoprotection Conferred to Pancreatic Islet by Human Amniotic Epithelial Cells
VANGUARD partners from UNIGE have published a new review article on Mechanisms of Immunomodulation and Cytoprotection Conferred to Pancreatic Islet by Human Amniotic Epithelial Cells in Stem Cell Reviews and Reports. The article is available open access and can be read here: https://link.springer.com/article/10.1007/s12015-021-10269-w Abstract Inhibiting pro-inflammatory cytokine activity can reverse inflammation mediated dysfunction of islet […]
