To introduce the VANGUARD project in easier to understand terms we have developed an infographic to explain the complex research happening in VANGUARD in a visual form.
VANGUARD is generating its first scientific outcomes, as seven works from the UNIGE group have recently been accepted and published in various journals such as Transplant International, Current Diabetes Report and Stem Cell Reviews and Reports:
Alibashe-Ahmed M, Berney T, Giovannoni L, Berishvili E (2020). Targeting Toll-Like Receptor 4: a promising strategy to prevent type 1 diabetes occurrence or recurrence. CellR4; 8: e2850.
Berishvili E, Kaiser L, Cohen M, Berney T, Scholz H, Floisand Y, Mattsson J (2020). Treatment of COVID-19 Pneumonia: the Case for Placenta-derived Cell Therapy. Stem Cell Reviews and Reports.
Berney T, Berishvili E (2020). I’ve got you under my skin. Nature Metabolism: News & Views.
Lebreton F, Wassmer CH, Bellofatto K, Berney T, and Berishvili E (2020). Organoïdes sécréteurs d’insuline : des «super-îlots» comme premier pas vers le pancréas bioartificiel. Med Sci (Paris), Volume 36, Number 10.
Wassmer CH, Bellofatto K, Perez L, Lavallard V, Cottet-Dumoulin D, Ljubicic S, Parnaud G, Bosco D, Berishvili E, Lebreton F (2020). Engineering of Primary Pancreatic Islet Cell Spheroids for Three-dimensional Culture or Transplantation: A Methodological Comparative Study. Cell Transplantation.
Wassmer CH, Berishvili E (2020). Immunomodulatory Properties of Amniotic Membrane Derivatives and Their Potential in Regenerative Medicine. Current Diabetes Reports volume 20, Article number: 31.
Wassmer CH, Lebreton F, Bellofatto K, Bosco D, Berney T, Berishvili E (2020). Generation of insulin-secreting organoids: a step toward engineering and transplanting the bioartificial pancreas. Transpl Int. 2020 Aug 27. doi: 10.1111/tri.13721.
Horizon, the official magazine for EU-funded research and innovation projects, has published an article about emerging treatments against diabetes. It includes an interview of the VANGUARD Coordinator Dr. Ekaterine Berishvili from the University of Geneva and a description of our project.
Dear followers of the VANGUARD project,
Since the VANGUARD website has been activated, we have received many messages from patients and their families enquiring about the possibility to enroll in the study.
We are grateful to have so many people interested in the project and following our progress. At the same time, we feel a great responsibility toward people living with type 1 diabetes and their families.
At this time, we are at the very start of the VANGUARD project. We have had a small delay in getting started due to the COVID-19 pandemic. In the coming years we will work on developing the individual parts of the VANGUARD product. Once the separate parts are ready, we will assemble them to form the complete bioartificial pancreas. In order to understand whether the individual parts and the assembled product work, we will carry out our research on small animals. This development phase will take 5 years. After this we hope to start studying how the bioartificial pancreas works in humans/people.
Before we can test the bioartificial pancreas in humans, we need to show that it works (i.e. that it effectively produces insulin) and that it is safe to use in humans. The whole VANGUARD consortium is committed to meet these challenges.
As part of this project we will be investigating the patient perspective on this product. What are patients’ thoughts, concerns or information needs? We will study this so we can take these things into consideration in the next phase of human testing. When we start this part of our research, we will post information on how you can participate on our social media platforms. We hope you will get involved!
In the meantime, we will post news on the VANGUARD project on our social media platforms to keep you informed on our progress and the milestones we have reached.
Thank you for your interest in the VANGUARD project and be assured that the whole VANGUARD team is committed to deliver the bioartificial pancreas for you in the hope of offering a new treatment for Type I diabetes in the future.
Ekaterine Berishvili, MD, PhD, project coordinator
On behalf of the VANGUARD consortium
New article published on Immunomodulatory Properties of Amniotic Membrane Derivatives and Their Potential in Regenerative Medicine
The VANGUARD coordinator, Ekaterine Berishvili together with Charles-Henri Wassmer have recently published a new article in Current Diabetes Reports on the Immunomodulatory Properties of Amniotic Membrane Derivatives and Their Potential in Regenerative Medicine.
Purpose of Review
During the last decades, the field of regenerative medicine has been rapidly evolving. Major progress has been made in the development of biological substitutes applying the principles of cell transplantation, material science, and bioengineering.
Among other sources, amniotic-derived products have been used for decades in various fields of medicine as a biomaterial for the wound care and tissue replacement. Moreover, human amniotic epithelial and mesenchymal cells have been intensively studied for their immunomodulatory capacities.
Amniotic cells possess two major characteristics that have already been widely exploited. The first is their ability to modulate and suppress the innate and adaptive immunities, making them a true asset for chronic inflammatory disorders and for the induction of tolerance in transplantation models. The second is their multilineage differentiation capacity, offering a source of cells for tissue engineering. The latter combined with the use of amniotic membrane as a scaffold offers all components necessary to create an optimal environment for cell and tissue regeneration. This review summarizes beneficial properties of hAM and its derivatives and discusses their potential in regenerative medicine.
Read the full article online: https://link.springer.com/article/10.1007/s11892-020-01316-w
More than 40 million individuals worldwide are affected by type 1 diabetes, which is the most common chronic disease in children and adolescents. Today’s primary treatment for diabetes is insulin therapy, which requires multiple injections every day to control a person’s blood sugar levels. This can potentially lead to chronic complications such as kidney-related issues (nephropathy), visual impairments (retinopathy) and ischemic heart disease. Beta-cell replacement, done either by pancreas or islet transplantation, is a valid alternative to daily injections, as it restores the possibility to control blood sugar levels (glucose). However, pancreas or islet transplantations rely on organ donors and require lifelong anti-rejection medication to avoid the rejection of the transplanted organ or cells. The process is also associated with complications and is currently only offered to a limited number of patients with severe forms of the disease.
Within the framework of a European funded H2020 project, VANGUARD aims to develop a cure for type 1 diabetes available to a larger group of patients. The VANGUARD project will use advanced tissue engineering techniques to generate a bioartificial pancreas, with the aim to propose a novel cell-based treatment to type 1 diabetes that overcomes the limitations inherent to current therapies. Working on this innovative solution is a multidisciplinary team of researchers from Switzerland, Italy, France, Germany and The Netherlands, led by Dr Ekaterine Berishvili from the University of Geneva, Department of Surgery. According to Dr. Berishvili “the VANGUARD multidisciplinary team will bring regenerative medicine for type I diabetes from bench to bedside”. In total, the project brings together outstanding expertise from six academic institutions with leading scientists in bioengineering, transplantation, gene therapy, immunology and ethics, two SMEs and an NGO.
VANGUARD’s bioartificial pancreas has the potential to improve the success rate of beta-cell replacement therapies with exceptional advantages in terms of efficacy and safety. The treatment of a large number of patients with type 1 diabetes could dramatically reduce the financial burden of the disease, mostly associated with the healthcare costs of chronic secondary complications of diabetes.
The VANGUARD project officially started and had its kick-off last month in January 2020, in conjunction with the annual symposium of the European Pancreas and Islet Transplant Association. Representatives from the nine project partners discussed the start of the research activities and the path towards what has the potential to be a real breakthrough towards a cure for type 1 diabetes.
University of Geneva
Dr Ekaterine Berishvili
Researcher and Coordinator of the VANGUARD project
Department of Surgery
Faculty of Medicine
The VANGUARD project is funded by the European research and innovation program Horizon 2020 (project number 874700), under the Health program. It is a five-year project that officially started in January 2020 and will end in December 2024. It involves nine project partners from seven European countries and has a budget of € 6.8 million.
Representatives from the eight VANGUARD partners travelled from across Europe to Igls in Austria to officially kick-off the project. The meeting took place on the 25th January 2020 and offered all partners the opportunity to get to know each other and their roles within the VANGUARD project in more detail.
The first VANGUARD meeting has been scheduled in Innsbruck, Austria for the 25th January 2020. Representatives from the 9 partners will travel to meet together for the first time to officially kick-off the VANGUARD project.
The project will run for 5 years and aims at delivering an Advanced Therapeutic Medicinal Product (ATMP) of high translational potential, with properties of increased functionality and implantability and protection from immune destruction. During the first meeting the partners will have the opportunity to introduce themselves and their role within the project which will contribute to the efficient implementation of the planned research and measures. We look forward to meeting the team who are taking part in this innovative project.